On December 20, 2014, it was revealed by Santa Cruz's agent, Aproniano Santa Cruz (his father), that the player would join Cruz Azul for the Clausura 2015. It was confirmed that Santa Cruz would travel to Mexico on December 22. December 2014 after playing his final league game for Málaga the day before, the signing itself would cost around €2 million with Santa Cruz's agent ensuring it would be a two-year contract. After the rumor that he was going to sign for Club Cerro Porteño, where he was in the lower ranks and of which his father is a fan (Aproniano is a member of the institution), finally in June 2016 he returned to Olimpia after seventeen years, after rescinding his contract with Cruz Azul. Santa Cruz scored his first league goal of the season in a 1-1 win against Las Palmas on 10 January 2016. It was his fourth La Liga appearance and the first time he would be in the starting eleven in a league match. Santa Cruz played in his last game for Málaga on December 21, 2014, in a 2-1 win against Elche.

On September 17, 2014, it was announced that Santa Cruz would be one of two team captains. Mourinho inexplicably left Chelsea on September 20, 2007, by "mutual consent" with the club's board of directors. He has played with her in the 2002, 2006 and 2010 World Cups, as well as the 1999 U-20 World Cup. He participated in the 1999, 2007, 2011 (where he was runner-up) and 2015 Copas América. He also played in the U-23 pre-Olympic of the year 2000 held in Londrina, Brazil. He subsequently won the 2018 Soccer World Cup, a tournament in which he scored four goals, earning him the Silver Boot as the tournament's second-highest scorer, won the Bronze Ball as third-best player, and was named man of the match in the final. In 1999, Santa Cruz represented the Paraguayan under-20s before receiving a call-up to the national soccer team, he was called up in the 20-man squad for the 1999 World Youth South American Championship in Argentina in January. On August 26, 2015, Santa Cruz returned to Málaga, having accepted a one-year loan deal. In October 1952, the plenary session of the Barcelona City Council approved an agreement that provided for the municipalisation of all the public transport companies in the city, thus affecting the Barcelona Metropolitan Railway, the Barcelona Metropolitan Railway and the Barcelona Tramways.

It has an area of ​​1,200,000 m², of which some 300,000 have been developed so far. The complex includes the medical and training facilities for the first teams, both male and female, and the lower soccer sections, as well as residences and twelve playing fields, including the Alfredo Di Stéfano Stadium where both the first subsidiary team play their matches, Real Madrid Castilla Club de Fútbol, ​​as the women's team. Santa Cruz had amounted to eight goals in 31 league games with Málaga in sixth position and they qualified for the 2013–14 UEFA Europa League play-off round, however the club was banned by UEFA from participating due to violations of the financial fair play regulation. Paraguay finished in first place in their respective group with 10 points, qualifying for the second round of the tournament. In the 2019 season, Santa Cruz scored no less than 28 goals, counting his 11 goals in the Apertura tournament, his 2 goals in the Copa Libertadores and his 15 cries in the Clausura tournament.

Spain was drawn in Group A of the tournament with the host Portuguese team, in addition to the Russian team and the Greek team, with which they had played the qualifying phase. At the end of the game, the president of Málaga, Abdullah Bin Nasser Al Thani, used his Twitter account to say goodbye to the Paraguayan striker, saying “Many thanks to Roque Santa Cruz. Roque Santa Cruz is the top scorer in the history of the Paraguayan team, with 32 goals and has played 112 games with it. In 2018, Roque registered 18 goals scored in the Apertura (4), Copa Libertadores (1), Clausura (9) and Copa Paraguay (4). On May 30, 2018, Santa Cruz played his 100th match with the dean shirt, playing against Club Libertad. On April 21, 2018, he directs the 2017-2018 Copa del Rey Final, Sevilla CF VS FC Barcelona (0-5), played at the Wanda Metropolitano. On both sides of the avenue were the main buildings of the Exposition: the Palace of Clothing, the Palace of Communications and Transport and the Palace of Metallurgy, Electricity and Motive Force; This architectural complex currently constitutes the Barcelona Trade Fair.